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Tivozanib hydrochloride hydrate
CAS No. 682745-41-1
Tivozanib hydrochloride hydrate( —— )
Catalog No. M35722 CAS No. 682745-41-1
Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is an orally active, selective, and potent vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, and VEGFR-3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | Get Quote |
|
| 10MG | 70 | Get Quote |
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| 25MG | 109 | Get Quote |
|
| 50MG | 159 | Get Quote |
|
| 100MG | 230 | Get Quote |
|
| 500MG | 574 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTivozanib hydrochloride hydrate
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NoteResearch use only, not for human use.
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Brief DescriptionTivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is an orally active, selective, and potent vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, and VEGFR-3.
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DescriptionTivozanib hydrochloride hydrate is a selective and orally activeVEGFR tyrosine kinase inhibitor with IC50 of 0.21, 0.16, 0.24 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. Tivozanib hydrochloride hydrate inhibits angiogenesis and vascular permeability in tumor tissues and shows antitumor activity. Tivozanib hydrochloride hydrate has the potential for the research of metastatic renal cell carcinoma (RCC).
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In VitroTivozanib hydrochloride hydrate inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.
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In VivoTivozanib hydrochloride hydrate (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%.
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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RecptorVEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number682745-41-1
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Formula Weight509.34
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Molecular FormulaC22H22Cl2N4O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (490.83 mM; Ultrasonic )
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SMILESO.Cl.COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Motzer RJ, et al. Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol. 2013 Oct 20;31(30):3791-9.?
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